SAR260301

Ligand id: 8793

Name: SAR260301

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 78.53
Molecular weight 354.17
XLogP 3.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-[2-[(2S)-2-methyl-2,3-dihydroindol-1-yl]-2-oxoethyl]-6-morpholin-4-yl-1H-pyrimidin-4-one
Synonyms
compound 28 [PMID: 24387221] | SAR-260301
Comments
SAR260301 (compound 28 [PMID: 24387221]) was reported in a discovery effort to optimize pyrimidone indoline amide inhibitors of PI3Kβ [2]. It is an orally bioavailable compound that is selective for PI3Kβ over other PI3 kinases.
Database Links
ChEMBL Ligand CHEMBL3112866
GtoPdb PubChem SID 252827451
PubChem CID 49854424
RCSB PDB Ligand J82
Search Google for chemical match using the InChIKey UAXHPOBBKRWJGA-ZDUSSCGKSA-N
Search Google for chemicals with the same backbone UAXHPOBBKRWJGA
Search UniChem for chemical match using the InChIKey UAXHPOBBKRWJGA-ZDUSSCGKSA-N
Search UniChem for chemicals with the same backbone UAXHPOBBKRWJGA