Compound class:
Natural product
Comment: Liquiritigenin is a bioactive natural flavonoid present in the root of Glycyrrhizae uralensis Fisch (a type of Chinese liquorice) [3]. We show the structure with (2S) stereochemistry.
The compound has reports of anticancer and anti-inflammatory actions, of providing protection from renal and hepatic injury [1-3], and behaving as a selective estrogen receptor β agonist [3]. The tissue-protective effects appear to center on activation of nuclear erythroid 2-related factor 2 (NRF2) signalling that induces expression of antioxidant enzymes [4,6]. ![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Natural product |
IUPAC Name ![]() |
(2S)-7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one |
Database Links ![]() |
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BindingDB Ligand | 50241408 |
CAS Registry No. | 578-86-9 (source: PubChem) |
ChEBI | CHEBI:28777 |
ChEMBL Ligand | CHEMBL252642 |
GtoPdb PubChem SID | 310264680 |
LIPID MAPS | LMPK12140061 |
PubChem CID | 114829 |
RCSB PDB Ligand | DFV |
Search Google for chemical match using the InChIKey | FURUXTVZLHCCNA-AWEZNQCLSA-N |
Search Google for chemicals with the same backbone | FURUXTVZLHCCNA |
UniChem Compound Search for chemical match using the InChIKey | FURUXTVZLHCCNA-AWEZNQCLSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | FURUXTVZLHCCNA-AWEZNQCLSA-N |