Compound class:
Endogenous peptide in human, mouse or rat
Comment: IL-34 is an endogenous ligand of the receptor tyrosine kinase, colony stimulating factor 1 receptor (CSF1R) [3]. It is a homodimeric cytokine.
Species: Human
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Bioactivity Comments |
IL-34-induced increase in monocyte viability is inhibited by the CSF1R inhibitor GW-2580 [3]. IL-34 sustains inflammatory pathways in the gut [2] and has been associated with obesity, chronic inflammation, and insulin resistance [1]. |
Natural/Endogenous Targets | ||
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Selectivity at catalytic receptors | ||||||||||||||||||||||||||||||||||
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