brivaracetam   Click here for help

GtoPdb Ligand ID: 9041

Synonyms: 2-(2-oxo-4-propylpyrrolidin-1-yl)butanamide | Briviact® | compound 83α [1] | UCB 34714 [3] | UCB-34714 | UCB34714
Approved drug PDB Ligand
brivaracetam is an approved drug (EMA & FDA (2016))
Compound class: Synthetic organic
Comment: Brivaracetam is a 4-n-propyl analogue of levetiracetam with anticonvulsant properties [3]. Like levetiracetam this drug inhibits synaptic vesicle protein 2A (SV2A), but with 10X higher binding affinity. Brivaracetam is brain penetrant and has a fast onset of action [2]. It can also inhibit sodium channels.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 63.4
Molecular weight 212.15
XLogP 0.8
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCCC1CN(C(=O)C1)C(C(=O)N)CC
Isomeric SMILES CCC[C@H]1CN(C(=O)C1)[C@H](C(=O)N)CC
InChI InChI=1S/C11H20N2O2/c1-3-5-8-6-10(14)13(7-8)9(4-2)11(12)15/h8-9H,3-7H2,1-2H3,(H2,12,15)/t8-,9+/m1/s1
InChI Key MSYKRHVOOPPJKU-BDAKNGLRSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA & FDA (2016))
IUPAC Name Click here for help
(2S)-2-[(4R)-2-oxo-4-propylpyrrolidin-1-yl]butanamide
International Nonproprietary Names Click here for help
INN number INN
8642 brivaracetam
Synonyms Click here for help
2-(2-oxo-4-propylpyrrolidin-1-yl)butanamide | Briviact® | compound 83α [1] | UCB 34714 [3] | UCB-34714 | UCB34714
Database Links Click here for help
BindingDB Ligand 50422531
CAS Registry No. 357336-20-0 (source: WHO INN record)
ChEMBL Ligand CHEMBL607400
DrugCentral Ligand 5068
GtoPdb PubChem SID 315661126
PubChem CID 9837243
RCSB PDB Ligand VLX
Search Google for chemical match using the InChIKey MSYKRHVOOPPJKU-BDAKNGLRSA-N
Search Google for chemicals with the same backbone MSYKRHVOOPPJKU
Search PubMed clinical trials brivaracetam
Search PubMed titles brivaracetam
Search PubMed titles/abstracts brivaracetam
UniChem Compound Search for chemical match using the InChIKey MSYKRHVOOPPJKU-BDAKNGLRSA-N
UniChem Connectivity Search for chemical match using the InChIKey MSYKRHVOOPPJKU-BDAKNGLRSA-N
Wikipedia Brivaracetam