vosoritide

Ligand id: 9068

Name: vosoritide

Structure and Physico-chemical Properties

2D Structure

Classification
Compound class	Peptide or derivative

International Nonproprietary Names
INN number	INN
10022	vosoritide

Synonyms
BMN 111 \| BMN-111

Synonyms

BMN 111 | BMN-111

Comments
Vosoritide is an investigational peptide analogue of C-type natriuretic peptide (CNP) with a longer half-life (duration of action) than the endogenous peptide [1]. It comprises the 37 C-terminal amino acids from human CNP with the addition of proline and glycine (PG) at its N-terminal. Vosoritide represents a novel mechanism which has the potential to treat fibroblast growth factor receptor 3-driven achondroplasia [1-2]. HELM annotation: PEPTIDE1{P.G.Q.E.H.P.N.A.R.K.Y.K.G.A.N.K.K.G.L.S.K.G.C.F.G.L.K.L.D.R.I.G.S.M.S.G.L.G.C}$PEPTIDE1,PEPTIDE1,23:R3-39:R3$$$.

Comments

Vosoritide is an investigational peptide analogue of C-type natriuretic peptide (CNP) with a longer half-life (duration of action) than the endogenous peptide [1]. It comprises the 37 C-terminal amino acids from human CNP with the addition of proline and glycine (PG) at its N-terminal.
Vosoritide represents a novel mechanism which has the potential to treat fibroblast growth factor receptor 3-driven achondroplasia [1-2].
HELM annotation: PEPTIDE1{P.G.Q.E.H.P.N.A.R.K.Y.K.G.A.N.K.K.G.L.S.K.G.C.F.G.L.K.L.D.R.I.G.S.M.S.G.L.G.C}$PEPTIDE1,PEPTIDE1,23:R3-39:R3$$$.

Database Links
CAS Registry No.	1480724-61-5 (source: WHO INN record)
GtoPdb PubChem SID	315661153
PubChem CID	119058036
Search Google for chemical match using the InChIKey	IGYWDDBBJPSOTG-WBAGYEQSSA-N
Search Google for chemicals with the same backbone	IGYWDDBBJPSOTG
Search PubMed clinical trials	vosoritide
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Search UniChem for chemical match using the InChIKey	IGYWDDBBJPSOTG-WBAGYEQSSA-N
Search UniChem for chemicals with the same backbone	IGYWDDBBJPSOTG