ogerin

Ligand id: 9155

Name: ogerin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 96.95
Molecular weight 307.14
XLogP 2.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
[2-[4-amino-6-(benzylamino)-1,3,5-triazin-2-yl]phenyl]methanol
Synonyms
ZINC67740571
Comments
In March 2016 ogerin was reported and named as a selective GPR68 positive allosteric modulator (PAM) [1]. It binds to the same allosteric binding site on GPR68 as lorazepam. Ogerin potentiates proton activity in GPR68-mediated Gs-cAMP production via increasing both proton affinity (α-cooperativity) and efficacy (β-cooperativity).
Database Links
GtoPdb PubChem SID 374883820
PubChem CID 56707820
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Tocris
Ogerin
Cat. No. 5722