Synonyms: cyclic [G(2',5')pA(3',5')p] | cyclic GMP-AMP | Cyclic guanosine monophosphate-adenosine monophosphate
Compound class:
Synthetic organic
Comment: 2'3'-cGAMP is produced in mammalian cells by the action of cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. It acts as an agonist of the human STING protein [2], but not of mouse Sting. 2'3'-cGAMP functions as a second messenger that binds to and activates the endoplasmic reticulum protein STING to trigger type-I IFNs production [1].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
Synonyms ![]() |
cyclic [G(2',5')pA(3',5')p] | cyclic GMP-AMP | Cyclic guanosine monophosphate-adenosine monophosphate |
Database Links ![]() |
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GtoPdb PubChem SID | 315661283 |
PubChem CID | 71563406 |
RCSB PDB Ligand | 1SY |
Search Google for chemical match using the InChIKey | XRILCFTWUCUKJR-INFSMZHSSA-N |
Search Google for chemicals with the same backbone | XRILCFTWUCUKJR |
Search UniChem for chemical match using the InChIKey | XRILCFTWUCUKJR-INFSMZHSSA-N |
Search UniChem for chemicals with the same backbone | XRILCFTWUCUKJR |
SynPHARM | 83677 (in complex with transmembrane protein 173) |
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2',3'-cGAMP sodium salt
Cat. No. 5945 |