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urocortin 2   Click here for help

GtoPdb Ligand ID: 921

Synonyms: urocortin II
Compound class: Endogenous peptide in human, mouse or rat
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Natural/Endogenous Targets
Target
CRF1 receptor
CRF2 receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CRF2 receptor Mm Agonist Full agonist 9.3 pKd - 2-3
⤷ pKd 9.3 [2-3]
CRF2 receptor Rn Agonist Full agonist 8.8 pKd - 2
⤷ pKd 8.8 [2]
CRF2 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 8.5 – 8.6 pKd - 1
⤷ pKd 8.5 – 8.6 [1]
CRF1 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 5.3 – 5.4 pKd - 1
⤷ pKd 5.3 – 5.4 [1]
Ligand mentioned in the following text fields
Corticotropin-releasing factor receptors overview