Synonyms: Dipeptide 9f [PMID 19175320] | GAP-134 | ZP-123
Compound class:
Peptide or derivative
Comment: Rotigaptide is a hexapeptide developed originally by Wyeth, as an anti-arrhythmic agent. It promotes electrical coupling between ventricular myocytes by increasing gap junction conductance [1]. A recent study showed reduction in myocardial infarction size in a porcine model and protection from IRI-related endothelial dysfunction in man. Rotigaptide may thus have therapeutic potential in the treatment of myocardial infarction [2].
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Classification | |
Compound class | Peptide or derivative |
IUPAC Name |
(2R,4S)-1-[(2R)-1-[(2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]-N-[2-[[(2R)-1-[(2-amino-2-oxoethyl)amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]-4-hydroxypyrrolidine-2-carboxamide |
International Nonproprietary Names | |
INN number | INN |
8717 | rotigaptide |
Synonyms |
Dipeptide 9f [PMID 19175320] | GAP-134 | ZP-123 |
Database Links | |
Specialist databases | |
Reactome Drug | R-ALL-9695396 |
Reactome Reaction | R-HSA-9695415 |
Other databases | |
CAS Registry No. | 355151-12-1 (source: PubChem) |
ChEMBL Ligand | ChEMBL450656 |
GtoPdb PubChem SID | 315661290 |
PubChem CID | 9938933 |
Search Google for chemical match using the InChIKey | GFJRASPBQLDRRY-TWTQBQJDSA-N |
Search Google for chemicals with the same backbone | GFJRASPBQLDRRY |
Search PubMed clinical trials | rotigaptide |
Search PubMed titles | rotigaptide |
Search PubMed titles/abstracts | rotigaptide |
UniChem Compound Search for chemical match using the InChIKey | GFJRASPBQLDRRY-TWTQBQJDSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | GFJRASPBQLDRRY-TWTQBQJDSA-N |
Wikipedia | Rotigaptide |