Synonyms: PXS4728A
Compound class:
Synthetic organic
Comment: VAP-1/SSAO (gene symbol AOC3) is an endothelial bound adhesion molecule with amine oxidase activity that is reported to be involved in neutrophil egress from the microvasculature during inflammation. The primary reference [3] indicates the potential of inhibiting this enzyme using PXS-4728A, as a therapeutic approach in lung diseases that are characterized by a neutrophilic pattern of inflammation. A more recent paper reports PXS-4728A-mediated suppression of airway inflammation and fibrosis, as well as improved lung function in experimental COPD [1]. Thirty nine analogues are exemplified in [2] but without discrete activity values.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
4-[(E)-2-(aminomethyl)-3-fluoroprop-2-enoxy]-N-tert-butylbenzamide |
Synonyms ![]() |
PXS4728A |
Database Links ![]() |
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GtoPdb PubChem SID | 328083448 |
PubChem CID | 71812247 |
Search Google for chemical match using the InChIKey | OWNSXNXYELKDSO-DHZHZOJOSA-N |
Search Google for chemicals with the same backbone | OWNSXNXYELKDSO |
UniChem Compound Search for chemical match using the InChIKey | OWNSXNXYELKDSO-DHZHZOJOSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | OWNSXNXYELKDSO-DHZHZOJOSA-N |