SKF-83566   Click here for help

GtoPdb Ligand ID: 944

Synonyms: SK&F-83566 | SK-83566 | SK83566
Compound class: Synthetic organic
Comment: SKF-83566 is a dopamine receptor antagonist with selectivity for D1/D5 compared to D2 [1,3].
Note we have corrected the name of this ligand from SKF-83556 to SKF-83566.
SKF-83566 (30 μM) is reported to inhibit adenylyl cyclase 2 (AC2) activity by ~95% in vitro [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 23.47
Molecular weight 331.06
XLogP 3.66
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O
Isomeric SMILES CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O
InChI InChI=1S/C17H18BrNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3
InChI Key XFTVOHWWEQGXLS-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
7-bromo-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol
Synonyms Click here for help
SK&F-83566 | SK-83566 | SK83566
Database Links Click here for help
BindingDB Ligand 50010301
ChEMBL Ligand CHEMBL324017
GtoPdb PubChem SID 135651055
PubChem CID 1243
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