SKF-83566

Ligand id: 944

Name: SKF-83566

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 23.47
Molecular weight 331.06
XLogP 3.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
7-bromo-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol
Synonyms
SK&F-83566 | SK-83566 | SK83566
Comments
SKF-83566 is a dopamine receptor antagonist with selectivity for D1/D5 compared to D2 [1,3].
Note we have corrected the name of this ligand from SKF-83556 to SKF-83566.
SKF-83566 (30 μM) is reported to inhibit adenylyl cyclase 2 (AC2) activity by ~95% in vitro [2].
Database Links
BindingDB Ligand 50010301
ChEMBL Ligand CHEMBL324017
GtoPdb PubChem SID 135651055
PubChem CID 1243
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