Compound class:
Synthetic organic
Comment: SPM-354 is a novel bitopic sphingosine 1-phosphate 3 receptor (SIP3R) antagonist [1]. SPM-354 competes for binding in both the orthosteric and allosteric sites, as defined by the natural ligand and the selective allosteric S1P3 positive allosteric modulator CYM-5541, respectively. SPM-354 is reference example 47 in WO2011004604.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
[(2S)-2-amino-2-[2-[2-chloro-4-[2-hydroxy-5-(trifluoromethyl)phenyl]sulfanylphenyl]ethyl]pentyl] dihydrogen phosphate |
Database Links ![]() |
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Specialist databases | |
GPCRdb Ligand | SPM-354 |
Other databases | |
GtoPdb PubChem SID | 329968433 |
PubChem CID | 49869062 |
Search Google for chemical match using the InChIKey | WDHXDLFPOPVGGO-IBGZPJMESA-N |
Search Google for chemicals with the same backbone | WDHXDLFPOPVGGO |
UniChem Compound Search for chemical match using the InChIKey | WDHXDLFPOPVGGO-IBGZPJMESA-N |
UniChem Connectivity Search for chemical match using the InChIKey | WDHXDLFPOPVGGO-IBGZPJMESA-N |