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ozoralizumab   Click here for help

GtoPdb Ligand ID: 9638

Synonyms: ATN-103 | PF-5230896
Immunopharmacology Ligand
Compound class: Antibody
Comment: Ozoralizumab is a trivalent albumin-binding nanobody that binds to and neutralises circulating TNFα. This biologic agent is being investigated for anti-inflammatory potential. The peptide sequence for ozoralizumab submitted in its WHO INN record is identical to SEQ ID NO: 96 (TNF30) in patent US8703131 [1], and identifies the albumin nanobody as ALB8. The patent claims a trivalent construct of TNF30-linker-ALB8-linker-TNF30.
Bioactivity Comments
Ozoralizumab binds serum albumin, in addition to TNFα, an action that increases its in vivo half-life [2].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
tumour necrosis factor shed form Primary target of this compound Hs Antibody Binding 9.0 pEC50 - 1
⤷ pEC50 9.0 (EC50 9.85x10-10 M) [1]