PF-04957325

Ligand id: 9659

Name: PF-04957325

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 136.11
Molecular weight 400.1
XLogP -0.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
3-[[(2R)-4-(1,3-thiazol-2-ylmethyl)morpholin-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine
Comments
PF-04957325 is a selective inhibitor of PDE8 [3] that is a useful chemical probe for studying the biological function of PDE8. It is compound 1-38 in patent WO2016030345 [2].
Database Links
CAS Registry No. 1305115-80-3 (source: PubChem)
GtoPdb PubChem SID 348353618
PubChem CID 52938379
Search Google for chemical match using the InChIKey VNLPYEMGHGDRRZ-MRVPVSSYSA-N
Search Google for chemicals with the same backbone VNLPYEMGHGDRRZ
Search UniChem for chemical match using the InChIKey VNLPYEMGHGDRRZ-MRVPVSSYSA-N
Search UniChem for chemicals with the same backbone VNLPYEMGHGDRRZ