diroleuton   Click here for help

GtoPdb Ligand ID: 9775

Synonyms: 8,11,14-Eicosatrienoic acid | DGLA | dihomo-gamma-linolenic acid | DS107 | Homo-gamma-linolenic acid
PDB Ligand Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Diroleuton (dihomo-gamma-linolenic acid; DGLA) is a 20-carbon-chain fatty acid that is structurally very similar to arachadonic acid (AA). It competes with AA for binding to the substrate binding sites of the COX and lipoxygenase enzymes, and this effect reduces the production of inflammatory mediators (eicosanoids) from AA. DGLA can be converted to PGE1 and eicosapentaenoic acid (EPA), the latter being a precursor for the synthesis of series-3 prostaglandins, series-5 leukotrienes and series-3 thromboxanes.

diroleuton is commercially available from our sponsors

2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 15
Topological polar surface area 37.3
Molecular weight 306.26
XLogP 8.68
No. Lipinski's rules broken 2

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES CCCCCC=CCC=CCC=CCCCCCCC(=O)O
Isomeric SMILES CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)O
InChI InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
InChI Key HOBAELRKJCKHQD-QNEBEIHSSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
(8Z,11Z,14Z)-icosa-8,11,14-trienoic acid
International Nonproprietary Names Click here for help
INN number INN
10359 diroleuton
Synonyms Click here for help
8,11,14-Eicosatrienoic acid | DGLA | dihomo-gamma-linolenic acid | DS107 | Homo-gamma-linolenic acid
Database Links Click here for help
CAS Registry No. 1783-84-2 (source: WHO INN record)
ChEMBL Ligand CHEMBL465183
GtoPdb PubChem SID 354702248
LIPID MAPS LMFA01030158
PubChem CID 5280581
RCSB PDB Ligand LAX
Search Google for chemical match using the InChIKey HOBAELRKJCKHQD-QNEBEIHSSA-N
Search Google for chemicals with the same backbone HOBAELRKJCKHQD
Search PubMed clinical trials diroleuton
Search PubMed titles diroleuton
Search PubMed titles/abstracts diroleuton
UniChem Compound Search for chemical match using the InChIKey HOBAELRKJCKHQD-QNEBEIHSSA-N
UniChem Connectivity Search for chemical match using the InChIKey HOBAELRKJCKHQD-QNEBEIHSSA-N

Product suppliers

View disclaimer

Sponsored products disclaimer

Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.

✖

MedChemExpress
Dihomo-γ-linolenic acid (links to external site)
Cat. No. HY-A0143