difamilast

Ligand id: 9776

Name: difamilast

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 11
Topological polar surface area 82.82
Molecular weight 446.17
XLogP 4.74
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[[2-[4-(difluoromethoxy)-3-propan-2-yloxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide
International Nonproprietary Names
INN number INN
10717 difamilast
Synonyms
example 352 [WO2007058338] | MM36 | OPA-15406
Comments
Difamilast (OPA-15406) is a topical, selective, nonsteroidal PDE4 inhibitor that is being developed for the treatment of atopic dermatitis [1]. The chemical structure is claimed as example 352 in patent WO2007058338 [2].
Database Links
CAS Registry No. 937782-05-3 (source: WHO INN record)
GtoPdb PubChem SID 354702249
PubChem CID 57855696
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