derazantinib

Ligand id: 9785

Name: derazantinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 59.07
Molecular weight 468.23
XLogP 4.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(6R)-6-(2-fluorophenyl)-N-[3-[2-(2-methoxyethylamino)ethyl]phenyl]-5,6-dihydrobenzo[h]quinazolin-2-amine
International Nonproprietary Names
INN number INN
10488 derazantinib
Synonyms
ARQ-087 | ARQ087
Comments
Derazantinib (ARQ087) is an orally bioavailable, non-selective FGFR inhibitor being investigated for antineoplastic activity. Preclinical activity is reported by Hall et al. (2016) [1].
Database Links
CAS Registry No. 1234356-69-4 (source: WHO INN record)
GtoPdb PubChem SID 354702258
PubChem CID 46834118
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