derazantinib   Click here for help

GtoPdb Ligand ID: 9785

Synonyms: ARQ-087 | ARQ087
Compound class: Synthetic organic
Comment: Derazantinib (ARQ087) is an orally bioavailable, non-selective FGFR inhibitor being investigated for antineoplastic activity. Preclinical activity is reported by Hall et al. (2016) [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 59.07
Molecular weight 468.23
XLogP 4.73
No. Lipinski's rules broken 0
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Canonical SMILES COCCNCCc1cccc(c1)Nc1ncc2c(n1)c1ccccc1C(C2)c1ccccc1F
Isomeric SMILES COCCNCCc1cccc(c1)Nc1ncc2c(n1)c1ccccc1[C@@H](C2)c1ccccc1F
InChI InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24-10-4-5-12-27(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16,18H2,1H3,(H,32,33,34)/t26-/m1/s1
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
10488 derazantinib
Synonyms Click here for help
ARQ-087 | ARQ087
Database Links Click here for help
CAS Registry No. 1234356-69-4 (source: WHO INN record)
GtoPdb PubChem SID 354702258
PubChem CID 46834118
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