futibatinib

Ligand id: 9786

Name: futibatinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 108.39
Molecular weight 418.18
XLogP 2.77
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]pyrazolo[3,4-d]pyrimidin-1-yl]pyrrolidin-1-yl]prop-2-en-1-one
International Nonproprietary Names
INN number INN
10879 futibatinib
Synonyms
Example 2 [WO2013108809] | FGFR-IN-1 | TAS 120 | TAS-120 | TAS120
Comments
Futibatinib (TAS-120) is a non-selective FGFR inhibitor being investigated for antineoplastic activity. It is claimed as Example 2 in patent WO2013108809 [1].
Database Links
BindingDB Ligand 161389
CAS Registry No. 1448169-71-8 (source: WHO INN record)
ChEMBL Ligand CHEMBL3701238
GtoPdb PubChem SID 354702259
PubChem CID 71621331
RCSB PDB Ligand TZ0
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