imaprelimab   

GtoPdb Ligand ID: 9805

Synonyms: PRX-003 | PRX003
Compound class: Antibody
Comment: Imaprelimab (PRX-003) is an anti-MCAM mAb developed as a novel therapy for psoriasis. In patients with autoimmune diseases, a subset of MCAM+ve T cells (which have an effector memory T-helper 17 phenotype) produce high levels of pro-inflammatory IL-17 [1,3]. Pharmacological disruption of MCAM function is thought to be a valid mechanism for the treatment of autoimmune inflammation. Peptide sequence alignments identify imaprelimab as one of the preferred antibodies claimed in patent WO2014039975 [2] (SEQ IDs 119 and 123 match the sequences submitted to the WHO for INN imaprelimab). These peptide sequences map to the construct identified as h2120VH5/L3.
Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
10753 imaprelimab
Synonyms
PRX-003 | PRX003
Database Links
Specialist databases
IMGT/mAb-DB 808
Other databases
GtoPdb PubChem SID 354702277
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