praliciguat   Click here for help

GtoPdb Ligand ID: 9900

Synonyms: IW-1973 | IW1973
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Praliciguat (IW-1973) is a potent, orally available soluble guanylyl cyclase (sGC) stimulator [3]. sGC stimulators/activators have potential as heart failure therapeutics [1]. Praliciguat exhibits anti-hypertensive, reno-protective, anti-fibrotic effects and anti-inflammatory activities. Effects observed in renal fibrosis models suggests potential for the treatment of diabetic nephropathy.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 101.89
Molecular weight 534.11
XLogP 5.42
No. Lipinski's rules broken 1
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Canonical SMILES Fc1cnc(nc1NCC(C(F)(F)F)(C(F)(F)F)O)c1nn(c(c1)c1nocc1)Cc1ccccc1F
Isomeric SMILES Fc1cnc(nc1NCC(C(F)(F)F)(C(F)(F)F)O)c1nn(c(c1)c1nocc1)Cc1ccccc1F
InChI InChI=1S/C21H14F8N6O2/c22-12-4-2-1-3-11(12)9-35-16(14-5-6-37-34-14)7-15(33-35)18-30-8-13(23)17(32-18)31-10-19(36,20(24,25)26)21(27,28)29/h1-8,36H,9-10H2,(H,30,31,32)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
10460 praliciguat
Synonyms Click here for help
IW-1973 | IW1973
Database Links Click here for help
CAS Registry No. 1628730-49-3 (source: WHO INN record)
GtoPdb PubChem SID 363894194
PubChem CID 86269973
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