Synonyms: ONO 5334 | ONO5334
Compound class:
Synthetic organic
Comment: ONO-5334 is a cysteine protease inhibitor with activity against cathepsin K. It was an oral drug lead that was considered as a bone resorption inhibitor for the treatment of postmenopausal osteoporosis. ONO-5334 has some antiviral activity against SARS-CoV-2, and antagonises viral replication in human iPSC-derived pneumocyte-like cells [2].
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Bioactivity Comments |
ONO-5334 impairs infection by SARS-CoV-2 in vitro with an EC50 of around 500 nM [2]. |