Synonyms: Citreorosein | omega-Hydroxyemodin
Compound class:
Natural product or derivative
Comment: ω-Hydroxyemodin is a polyhydroxyanthraquinone isolated from Penicillium restrictum. It has been investigated as an alternative or adjunctive to conventional antibacterials in the treatment of antibacterial-resistant infections, including invasive skin and soft tissue infections (SSTIs) caused by Staphylococcus aureus [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
ω-Hydroxyemodin inhibited quorum sensing, with an IC50 of 8 μM in a clinical isolate of methicillin-resistant Staphylococcus aureus (MRSA) [2]. The compound has been shown to significantly reduce abscess and ulcer formation and to promote bacterial clearance in a mouse model of Staphylococcus aureus SSTI [1]. |