Compound class:
Synthetic organic
Comment: Sch 29482 is a penem antibacterial belonging to the β-lactam group. It is orally absorbed, has activity against both Gram-positive and Gram-negative bacteria (with the exception of Pseudomonas) and exhibits β-lactamase stability [1-2,4-5]. Sch 29482 has been dropped from developed for clinical use [3].
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Bioactivity Comments |
Sch 29482 has a broad-spectrum of activity against Gram-negative and Gram-positive bacteria but does not inhibit Pseudomonas. The MIC90 for antimicrobial activity is 3.1 μg/ml for Staphylococcus aureus and 0.4 μg/ml for Escherichia coli [5]. |