Compound class:
Natural product or derivative
Comment: Emetine is a plant metabolite from ipecac root.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
Emetine inhibits protein synthesis in eukaryotic cells. It also has reported antiviral activity. Although the antiviral mechanism is not fully resolved, it may involve blocking viral progress through the normal endocytic pathway [3-4]. Emetine has been reported to rescue SARS-CoV-2 infected Vero-E6 cells from death with an EC50 of <10 nM in plaque and CellTiter-Glo assays [2]. DrugMatrix in vitro pharmacology data indicates that emetine interacts with alpha adrenergic receptors and L type calcium channels [1]. |