compound 2 [PMID: 33085774]   Click here for help

GtoPdb Ligand ID: 11322

Antimalarial Ligand
Compound class: Synthetic organic
Comment: Compound 2 is a representative compound from a novel class of hybrid molecules, combining structural domains from azithromycin and chloroquine. It consists of an azalide scaffold linked to a chloroquinoline aromate and demonstrates improved antimalarial efficacy over the parent compounds [1].
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 16
Hydrogen bond donors 5
Rotatable bonds 13
Topological polar surface area 194
Molecular weight 966.57
XLogP 4.95
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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Canonical SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2OCCCNc2ccnc3c2ccc(c3)Cl)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O
Isomeric SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2OCCCNc2ccnc3c2ccc(c3)Cl)N(C)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O
InChI InChI=1S/C50H83ClN4O12/c1-15-39-50(10,60)43(56)32(6)55(13)27-28(2)25-48(8,59)45(30(4)41(31(5)46(58)65-39)66-40-26-49(9,61-14)44(57)33(7)64-40)67-47-42(38(54(11)12)23-29(3)63-47)62-22-16-20-52-36-19-21-53-37-24-34(51)17-18-35(36)37/h17-19,21,24,28-33,38-45,47,56-57,59-60H,15-16,20,22-23,25-27H2,1-14H3,(H,52,53)/t28-,29-,30+,31-,32-,33+,38+,39-,40+,41+,42-,43-,44+,45-,47+,48-,49-,50-/m1/s1
InChI Key KZRUOZJPVVJKAE-ZPHCEPPYSA-N
Bioactivity Comments
Compound 2 was assayed against a panel of Gram-positive bacteria and found to demonstrate only minor activity (M. catarrhalis, MIC 16 μg/ml) [1].
Whole organism assay data
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MOA/likely target Sp. Assay description Type Action Value Parameter Concentration range (M) Reference
Unknown MOA Pf7G8 Parasite growth inhibition assay - - 8.5 pIC50 - 1
pIC50 8.5 (IC50 3x10-9 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA PfV1/S Parasite growth inhibition assay - - 8.3 pIC50 - 1
pIC50 8.3 (IC50 5x10-9 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA PfK1 Parasite growth inhibition assay - - 8.3 pIC50 - 1
pIC50 8.3 (IC50 5x10-9 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA PfFCR3 Parasite growth inhibition assay - - 8.3 pIC50 - 1
pIC50 8.3 (IC50 5x10-9 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA Pf3D7 Parasite growth inhibition assay - - 8.2 pIC50 - 1
pIC50 8.2 (IC50 6x10-9 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA PfDd2 Parasite growth inhibition assay - - 8.2 pIC50 - 1
pIC50 8.2 (IC50 6x10-9 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA PfW2 Parasite growth inhibition assay - - 8.1 pIC50 - 1
pIC50 8.1 (IC50 7x10-9 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)