spexin-1   Click here for help

GtoPdb Ligand ID: 11417

Comment: Spexin-1 has been identified as an agonist of galanin receptors GALR2 and GALR3 [1-2]. It is a cleavage product of the 116 amino acid spexin precursor which is cleaved into two chains: spexin-1 and spexin-2 (FISDQSRRKDLSDRPLPE).
Species: Human
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Natural/Endogenous Targets
Target
GAL2 receptor
GAL3 receptor
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GAL2 receptor Ligand is endogenous in the given species Hs Agonist Agonist 6.8 pEC50 - 1
pEC50 6.8 (EC50 1.61x10-7 M) [1]
Description: Determined by measuring SRE-luc activity in HEK293-Gqi cells expressing hGALR2.
GAL3 receptor Ligand is endogenous in the given species Hs Agonist Agonist 6.2 pEC50 - 1
pEC50 6.2 (EC50 6.26x10-7 M) [1]
Description: Determined by measuring SRE-luc activity in HEK293-Gqi cells expressing hGALR3.