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GtoPdb Ligand ID: 11419

Comment: This is a synthetic, modified analogue of the endogenous galanin receptor 2/3 peptide ligand spexin-1[1-2]. It selectively activates signalling via GAL2 and is inactive at the GAL3 receptor [2].
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GAL2 receptor Hs Agonist Agonist 7.1 pEC50 - 1
pEC50 7.1 (EC50 8.71x10-8 M) [1]
Description: SRE-luc reporter activation in HEK293 Gqi cells expressing hGAL3 receptor.