Synonyms: EVO-984 | EVO984 | GS441524
Compound class:
Synthetic organic
Comment: GS-441524 is the parent nucleoside that is metabolically liberated from remdesivir. Both compounds block RNA transcription by inhibiting the viral RNA-dependent RNA polymerase (RdRP). GS-441524 is the major metabolite and persists in the circulation with a longer half-life than remdesivir. GS-441524 potently inhibits SARS-CoV-2 replication in in vitro and in vivoinfection models [1].
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Bioactivity Comments |
In Vero E6 cells the anti-SARS-CoV-2 potency of GS-441524 (IC50 0.7 μM) is greatter than that of remdesivir (IC50 1.35 μM) [1]. However the opposite is true in Calu-3 and Caco-2 cells, indicating cell-type dependent activities of the two compounds. |