Synonyms: Example 39 [WO2017175147A1]
Compound class:
Synthetic organic
Comment: DiABZI-4 is a non-dinucleotide STING agonist [2]. It has been shown to protect against SARS-CoV-2 infection in cells and in vivo in the K18-ACE2-transgenic mouse infection model. The compound is active via intranasal delivery. Its chemical structure is claimed in the same GSK patent as STING agonist 3 (diABZI STING agonist-1) [1].
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Bioactivity Comments |
Activation of STING by diABZI-4 during SARS-CoV-2 infection in the lung induces a rapid and transient antiviral response that is mediated via type I IFNs, NF-κB driven cytokine production and lymphocyte activation [2]. This mechanism inhibits viral replication and appears to prevent severe respiratory disease. |
Selectivity at other protein targets | ||||||||||||||||||||||||||||||||||
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