Synonyms: analog 15 [PMID: 24900473] | MK-5172 | MK5172 | Zepatier® [elbasvir (NS5A inhibitor) + grazoprevir]
grazoprevir is an approved drug (FDA (2016), UK (2021))
Compound class:
Synthetic organic
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Bioactivity Comments |
MK-5172 is active against HCV genotype 1-3 NS3/4a and clinically relevant mutant enzymes. Ki vs. wild type genotype 1b and 3a NS3/4a's are 0.02 and 0.7 nM respectively [2]. |