Synonyms: GR-43659X | GR43659X | GX 1048 | GX-1048 | GX1048 | Lacipil® | Molap® | Motens®
lacidipine is an approved drug (UK (2013))
Compound class:
Synthetic organic
Comment: Lacidipine (GR-43659X) is dihydropyridine calcium channel blocker. It has a slow onset of activity and a long duration of action.
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Bioactivity Comments |
Like manidipine, lacidipine is selective for calcium channels in vascular smooth muscle. Lacidipine inhibits K+-stimulated increase in cytosolic free Ca2+ in rat A7r5 vascular smooth muscle cells with an IC50 of 2.76 nM [1]. |