peptide YY   Click here for help

GtoPdb Ligand ID: 1515

Abbreviated name: PYY
Synonyms: peptide tyrosine tyrosine
Comment: The mouse, rat and pig sequences are identical. See the post-translational modifications for possible species-differences
Species: Mouse, Rat, Pig
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Natural/Endogenous Targets
Target
Y1 receptor
Y2 receptor
Y4 receptor
Y5 receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Y1 receptor Ligand is endogenous in the given species Rn Agonist Full agonist 10.2 pKi - 2
pKi 10.2 [2]
Y2 receptor Rn Agonist Full agonist 10.0 pKi - 4
pKi 10.0 [4]
Y2 receptor Hs Agonist Full agonist 9.5 pKi - 3
pKi 9.5 [3]
Y5 receptor Ligand is endogenous in the given species Rn Agonist Full agonist 9.0 pKi - 6
pKi 9.0 [6]
Y5 receptor Hs Agonist Full agonist 8.9 pKi - 6
pKi 8.9 [6]
Y4 receptor Ligand is endogenous in the given species Rn Agonist Full agonist 6.3 – 8.5 pKi - 2,7
pKi 6.3 – 8.5 [2,7]
pKi 6.3 [7]
Y4 receptor Ligand is endogenous in the given species Mm Agonist Full agonist 6.3 – 8.5 pIC50 - 5
pIC50 6.3 – 8.5 [5]