[Leu31,Pro34]NPY   Click here for help

GtoPdb Ligand ID: 1545

Synonyms: [Leu31,Pro34] neuropeptide Y | [Leu31,Pro34]-NPY
Comment: Synthetic analogue of the human/rodent NPY natural pepide sequence
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Y1 receptor Rn Agonist Full agonist 10.6 pKi - 2
pKi 10.6 [2]
Y4 receptor Hs Agonist Full agonist 7.7 pKi - 6
pKi 7.7 [6]
Y2 receptor Hs Agonist Full agonist 6.2 pKi - 3
pKi 6.2 [3]
Y1 receptor Hs Agonist Agonist 7.1 pEC50 - 1
pEC50 7.1 (EC50 7.87x10-8 M) [1]
Y4 receptor Mm Agonist Full agonist 8.4 – 9.5 pIC50 - 4
pIC50 8.4 – 9.5 [4]
Y1 receptor Rn Agonist Full agonist 8.0 – 8.6 pIC50 - 5
pIC50 8.0 – 8.6 [5]