ω-grammotoxin SIA   Click here for help

GtoPdb Ligand ID: 2539

Synonyms: ω-GrTx SIA | omega-grammotoxin SIA | omega-GsTx SIA | omega-GTX SIA
Comment: ω-Grammotoxin SIA (GrTx) is a 36 amino acid residue protein toxin from the venom of the spider Grammostola rosea (Chilean rose tarantula) [3].
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Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Cav2.2 Rn Gating inhibitor Antagonist - - 5x10-7 2
Conc range: 5x10-7 M [2]
Voltage: -80.0 mV
Cav2.1 Rn Gating inhibitor Antagonist 6.7 – 7.1 pIC50 - 1-2
pIC50 6.7 – 7.1 [1-2]
Voltage: Physiological