jingzhaotoxin-III   Click here for help

GtoPdb Ligand ID: 2574

Synonyms: β-theraphotoxin-Cj1a | β-TRTX-Cj1a | Jingzhaotoxin-3 | JZTX-III
Comment: From Chilobrachys jingzhao (Chinese earth tiger tarantula)
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Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Nav1.5 Hs Gating inhibitor Voltage-dependent inhibition 6.5 pKi - 2
pKi 6.5 [2]
Voltage: -80.0 mV
Description: Whole-cell voltage clamp of human embryonic kidney cells (HEK293) transfected with human Nav1.5.
Kv2.1 Rn Gating inhibitor - 6.4 pIC50 - 1
pIC50 6.4 (IC50 3.8x10-7 M) [1]