2-oleoyl-LPA   Click here for help

GtoPdb Ligand ID: 2936

Synonyms: 2-acyl-1LPA | 2Acyl-LPA
Compound class: Metabolite or derivative
Comment: 2-oleoyl-LPA is a mammalian metabolite.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 21
Topological polar surface area 123.1
Molecular weight 436.26
XLogP 5.9
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCCCCCCCC=CCCCCCCCC(=O)OC(COP(=O)(O)O)CO
Isomeric SMILES CCCCCCCC/C=C\CCCCCCCC(=O)OC(COP(=O)(O)O)CO
InChI InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)28-20(18-22)19-27-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-
InChI Key ZOOLJLSXNRZLDH-KTKRTIGZSA-N
Natural/Endogenous Targets
Target
GPR35
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
LPA2 receptor Hs Agonist Agonist 8.0 pEC50 - 1
⤷ pEC50 8.0 [1]
LPA3 receptor Hs Agonist Agonist 8.0 pEC50 - 1
⤷ pEC50 8.0 [1]
GPR35 Ligand is endogenous in the given species Hs Agonist Agonist 7.3 – 7.5 pEC50 - 5
⤷ pEC50 7.3 – 7.5 [5]
LPA1 receptor Hs Agonist Agonist 6.7 pEC50 - 1
⤷ pEC50 6.7 [1]
Targets where the ligand is described in the comment field
Target Comment
GPR35 Several studies have shown that kynurenic acid is an agonist of GPR35 but it remains controversial whether the proposed endogenous ligand reaches sufficient tissue concentrations to activate the receptor [4]. 2-Oleoyl-LPA has also been proposed as an endogenous ligand [5] but these results were not replicated in an arrestin assay [6]. The phosphodiesterase inhibitor zaprinast [7] has become widely used as a surrogate agonist to investigate GPR35 pharmacology and signalling [7]. GPR35 is also activated by the pharmaceutical adjunct pamoic acid [8]. See reviews [2] and [3].