Synonyms: dihydro-β-erythroidine
Compound class:
Synthetic organic
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Commonly used antagonists at nicotinic acetylcholine receptor α2 subunit | α2β2: DHβE (KB = 0.9 μM), tubocurarine (KB = 1.4 μM); α2β4: DHβE (KB = 3.6 μM), tubocurarine (KB = 4.2 μM) | |
Commonly used antagonists at nicotinic acetylcholine receptor α3 subunit | α3β2: DHβE (KB = 1.6 μM, IC50 = 2.0 μM), tubocurarine (KB = 2.4 μM); α3β4: DHβE (KB = 19 μM, IC50 = 26 μM), tubocurarine (KB = 2.2 μM) | |
Commonly used antagonists at nicotinic acetylcholine receptor α4 subunit | α4β2: DHβE (KB = 0.1 μM; IC50 = 0.08 - 0.9 μM), tubocurarine (KB = 3.2 μM, IC50 = 34 μM); α4β4: DHβE (KB = 0.01 μM, IC50 = 0.19 – 1.2 μM), tubocurarine (KB = 0.2 μM, IC50 = 50 μM) | |
Commonly used antagonists at nicotinic acetylcholine receptor α6 subunit | α6/α3β2β3 chimera: DHβE (IC50 = 1.1 μM) | |
Commonly used antagonists at nicotinic acetylcholine receptor α7 subunit | (α7)5: DHβE (IC50 = 8 - 20 μM); (α7)5: tubocurarine (IC50 = 3.1 μM) |