uridine   Click here for help

GtoPdb Ligand ID: 4566

PDB Ligand
Compound class: Metabolite or derivative
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 124.78
Molecular weight 244.07
XLogP -1.42
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES OCC1OC(C(C1O)O)n1ccc(=O)[nH]c1=O
Isomeric SMILES OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1ccc(=O)[nH]c1=O
InChI InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
InChI Key DRTQHJPVMGBUCF-XVFCMESISA-N
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
Ecto-5'-Nucleotidase
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Sodium/nucleoside cotransporter 1
Solute carrier family 28 member 3
Equilibrative nucleoside transporter 1 3
Equilibrative nucleoside transporter 2
Equilibrative nucleoside transporter 3 1
Sodium-dependent nucleobase transporter 2
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Endogenous substrates at Sodium-dependent nucleobase transporter uracil > thymine > guanine, hypoxanthine > xanthine, uridine 2
Endogenous substrates in order of increasing Km: at Equilibrative nucleoside transporter 1 adenosine < inosine < uridine < guanosine < cytidine < hypoxanthine < adenine < thymine