IL-22   Click here for help

GtoPdb Ligand ID: 4988

Synonyms: cytokine Zcyto18 | interleukin-22
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-22 is an IL-10 superfamily type II cytokine which plays a key role during inflammatory responses, and has potent neutrophil chemoattractant activity. It is regulated in part by IL-23. IL-22 has been demonstrated to play an important protective function in the gut where it promotes anti-microbial peptide expression. Via induction of intestinal epithelial stem cell proliferation, IL-22 is involved in gut barrier recovery after acute injury [2]. Conversely, IL-22 has also been implicated as a driving factor in chronic gut pathologies [5].
Species: Human
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
Natural/Endogenous Targets
Target
Interleukin-22α1/10β heteromer
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-22α1/10β heteromer Ligand is endogenous in the given species Hs Agonist Agonist 11.5 pEC50 - 6
⤷ pEC50 11.5 (EC50 3.5x10-12 M) [6]
Description: EC50 for rhIL-22-induced STAT3 activation in HEK293 cells that overexpress the human IL-22 heterodimeric receptor
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
fezakinumab Peptide Primary target of this compound Hs Antibody Binding 10.3 pKd - 1
⤷ pKd 10.3 (Kd 5.4x10-11 M) [1]
Description: Binding in an ELISA using immobilized human IL-22
Targets where the ligand is described in the comment field
Target Comment
Interleukin-22 receptor α2 Soluble decoy receptor that binds IL-22 (IL22, Q9GZX6) as a monomer.