GxTx-1E   Click here for help

GtoPdb Ligand ID: 7760

Synonyms: κ-theraphotoxin-Pg1a | κ-TRTX-Pg1a | guangxitoxin-1E
Comment: GxTX-1E is a 36 amino acid peptide toxin found in the venom of the tarantula Plesiophrictus guangxiensis [1]. It blocks voltage-gated Kv2.1 potassium channel currents [1],
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Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kv2.2 Hs Gating inhibitor - 8.6 pKd - 1
pKd 8.6 (Kd 2.6x10-9 M) [1]
Kv2.1 Hs Gating inhibitor - 2.0 pIC50 - 1
pIC50 2.0 [1]