Compound class:
Synthetic organic
Comment: The chemical structure shown here was drawn from [1]. LUF6200 acts as an inhibitory allosteric modulator of the human ether-à-go-go (hERG) K+ channel, with respect to astemizole and dofetilide, but displays positive co-operativity with K+ ions [1].
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Bioactivity Comments |
LUF6200 accelerates the dissociation of [3H]astemizole and [3H]dofetilide in a concentration-dependent manner, with EC50 values of 4900nM and 3400nM repectively [1]. |