|
Synonyms: GC1008 | PET1073G12 [1]
Compound class:
Antibody
Comment: Fresolimumab is a monoclonal antibody targeting all isoforms of transforming growth factor beta (TGF-β1, -β2 and -β3.).
Annotated peptide sequence information for this antibody is available from its IMGT/mAb-DB link. BLAST peptide sequence analysis reveals patent US7723486 as the covering document for fresolimumab [1]. |
| Bioactivity Comments |
| In cellular proliferation assays fresolimumab (coded as PET1073G12) neutralises the proliferative effects of TGF-β1, TGF-β2 and TGF-β3 with IC50 values of 0.44-0.8nM, 12-13nM and 2.8-6nM respectively [1]. Binding affinity values are not provided in the associated patent. |
| Selectivity at ligand targets | ||||||||||||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||
