|
Compound class:
Antibody
Comment: LY2928057 is an investigational anti-ferroportin monoclonal being developed as a treatment for anemia. A search of patents reveals WO2010065496 A1 as Eli Lilly's application covering the development and use of anti-ferroportin 1 monoclonal antibodies [1]. The HGNC approved gene symbol for ferroportin 1 is SLC40A1.
|
| Bioactivity Comments |
| In WO2010065496 the only humanised clone accompanied with a Kd for ferropotin binding is human 3D8. The Kd value is 3.37nM [1]. This clone also inhibits ferrorortin internalisation and degradation with an IC50 value of 13.7nM. We have tagged SLC40A1 as the primary target of this antibody based on the patent contents. |
| Selectivity at transporters | ||||||||||||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||
