MM-111   Click here for help

GtoPdb Ligand ID: 8931

Synonyms: 
Compound class: Antibody
Comment: MM-111 is a bispecific antibody fusion protein that co-targets the epidermal growth factor family receptor tyrosine kinases, ERBB2 and ERBB3 [1].
Annotated peptide sequences for this construct are available from its IMGT/mAb-DB record.
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Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
erb-b2 receptor tyrosine kinase 2 Primary target of this compound Hs Antibody Binding 9.5 pKd - 1
pKd 9.5 (Kd 3x10-10 M) [1]
erb-b2 receptor tyrosine kinase 3 Primary target of this compound Hs Antibody Binding 7.8 pKd - 1
pKd 7.8 (Kd 1.561x10-8 M) [1]