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Synonyms: Boc-Gln-D-Trp(CH0)-Phe-OBzl | Nα-[Nα-[Nα-(tert-butyloxycabonyl)-L-glutaminyl]-N1-formyl-D-tryptophyl-L-phenylalanine benzyl ester
Compound class:
Peptide or derivative
Comment: QWF was originally identified as a tripeptide derivative of the substance P-derived octapeptide and NK1 receptor selective antagonist D-Pro-Gln-Gln-D-TrpPhe-D-Trp-D-Trp-Phe-NH2 [2]. It has more recently been reported to antagonise MRGPRX2 [1], and is claimed in patent WO2016118632 which covers the use of QWF derivatives as MRGPRX2 antagonists for the prevention and treatment of itch [3].
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| Bioactivity Comments |
| QWF is rapidly metabolized in plasma which limits its in vivo efficacy. |
| Selectivity at GPCRs | ||||||||||||||||||||||||||||||||||
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