Synonyms: BMS962212 | compound 55 [PMID: 29077405]
Compound class:
Synthetic organic
Comment: BMS-962212 is a reversible, direct, and highly selective small molecule inhibitor of the serine protease FXIa [2].
|
|
Bioactivity Comments |
BMS-962212 has a potent FXIa binding affinity (Ki 0.7 nM), good in vitro and in vivo anticoagulant activity, acceptable aqueous solubility, a favourable PK profile, and no off-target activity [2], all of which indicate its suitability as a candidate parenteral anti-thrombotic agent. |