Synonyms: Citreorosein | omega-Hydroxyemodin
Compound class:
Natural product or derivative
Comment: ω-Hydroxyemodin is a polyhydroxyanthraquinone isolated from Penicillium restrictum. It has been investigated as an alternative or adjunctive to conventional antibacterials in the treatment of antibacterial-resistant infections, including invasive skin and soft tissue infections (SSTIs) caused by Staphylococcus aureus [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Mechanism Of Action and Pharmacodynamic Effects |
The expression of virulence factors by pathogenic bacteria is controlled by quorum sensing (QS), a process of cell to cell communication that bacteria use to share information about cell density [3]. ω-Hydroxyemodin inhibits Staphylococcus aureus QS-dependent virulence, mediated by the accessory gene regulator (agr), while indirectly bolstering the host immune response [1]. |