Synonyms: ARV-110 | ARV110 | compound 406 [WO2018071606A1]
Compound class:
Synthetic organic
Comment: Bavdegalutamide (ARV110) is a bifunctional degarder class compound (PROTAC). One end of the molecule binds to the androgen receptor and the other binds to the cereblon E3 ligase and directs the AR for proteasome-mediated degradation [1]. It has clinical potential as an oral therapy for metastatic castration-resistant prostate cancer. PubChem CID 134414307 represents the molecule without specified stereo chemistry.
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Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT03888612 | Trial of ARV-110 in Patients With Metastatic Castration Resistant Prostate Cancer | Phase 1/Phase 2 Interventional | Arvinas Inc |