ABBV-CLS-484   Click here for help

GtoPdb Ligand ID: 11968

Synonyms: AC484
PDB Ligand
Compound class: Synthetic organic
Comment: ABBV-CLS-484 is an orally bioavailable, active-site inhibitor of the protein tyrosine phosphatases PTPN1/N2 that was developed by AbbVie, Calico Life Sciences, and the Broad Institute of MIT and Harvard. Its chemical structure was first disclosed at the AACR spring meeting in 2022, and subsequently published in a Nature Communications article in mid-2023 [2]. ABBV-CLS-484-mediated inhibition of PTPN1/N2 in T cells promotes a potent immune-dependent anti-tumour effect[1].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 107.12
Molecular weight 385.15
XLogP 2.15
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC(CCN[C@@H]1CCc2c(C1)c(F)c(c(c2)O)N1CC(=O)NS1(=O)=O)C
Isomeric SMILES CC(C)CCN[C@@H]1CCc2c(C1)c(F)c(N1CC(=O)NS1(=O)=O)c(O)c2
InChI InChI=1S/C17H24FN3O4S/c1-10(2)5-6-19-12-4-3-11-7-14(22)17(16(18)13(11)8-12)21-9-15(23)20-26(21,24)25/h7,10,12,19,22H,3-6,8-9H2,1-2H3,(H,20,23)/t12-/m1/s1
InChI Key DVFCRTGTEXUFIN-GFCCVEGCSA-N
No information available.
Summary of Clinical Use Click here for help
Initially the safety, PK and PD of ABBV-CLS-484 will be assessed in eligible patients with advanced solid tumours, and then its efficacy either as monotherapy or in combination with a PD-1 (checkpoint) inhibitor will be determined.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT04777994 A Phase 1 Study With ABBV-CLS-484 in Subjects With Locally Advanced or Metastatic Tumors Phase 1 Interventional Calico Life Sciences LLC