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cocaine is an approved drug
Compound class: Natural product or derivative
Comment: Cocaine is a tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. Topically applied cocaine has local anesthetic effects, causing loss of feeling or numbness. It also causes vasoconstriction.
There is no information on the US Drugs@FDA website regarding marketing approval for formulations of this drug.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Summary of Clinical Use|
|Used as a local anaesthetic in nasal, oral and laryngeal surgery.|
|Mechanism Of Action and Pharmacodynamic Effects|
|The local anaesthetic action of cocaine is a result of its inhibition of sodium channels which results in inhibition of excitation at nerve endings and inhibition of peripheral nerve conductance. Vasoconstriction results from inhibition of noradrenaline reuptake. In pre-synaptic neurons cocaine prevents the re-uptake of dopamine, serotonin, and noradrenaline. Inhibiting dopamine re-uptake likely accounts for the development of cocaine addiction.|